๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Trifluoroacetimidoyl chlorides as a new trifluoromethyl building block for fluorinated nitrogen heterocycles

โœ Scribed by Kenji Uneyama; Osamu Morimoto; Fumio Yamashita

Book ID
104232961
Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
210 KB
Volume
30
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

N-Substituted trifluoroacetimidoyl chlorides have been prepared and allowed to react with various carbon nucleophiles, affording trifluoromethyl ketimines. Organofluorine compounds have accepted an increasing attentions.') Among them, preparations of trifluoromethylated compounds are in great demand because of their unique nature for biological activities and high performance material science. Trifluoroacetic acid is one of the most available and economically feasible starting materials for trifluoromethylated compounds.

๐Ÿ“œ SIMILAR VOLUMES

2,2,2-Trifluoroacetamidins as new triflu
2,2,2-Trifluoroacetamidins as new trifluoromethyl building blocks for fluorinated nitrogen heterocycles
โœ Kenji Uneyama; Koji Sugimoto; Osamu Morimoto; Fumio Yamashita; Masashi Kobayashi ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 40 KB

2,2,2-Trifluoroacetimidoyl chlorides 1 are much more stable than the corresponding nonfluorinated chlorides because of the deactivation for hydrolysis by the strong electronwithdrawing fluorine atom and thus useful as synthetic blocks. They react smoothly with nucleophilics such as Grignard reagent