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2-18F-phenylalanine and 3-18f-tyrosine — synthesis and preliminary data of tracer kinetics

✍ Scribed by M. Murakami; K. Takahashi; Y. Kondo; S. Mizusawa; H. Nakamichi; H. Sasaki; E. Hagami; H. Iida; I. Kanno; S. Miura; K. Uemura

Book ID
102368447
Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
330 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

2-1eF-phenylalanine and 3-leF-tyrosine were synthesized by direct electro hilic substitution of L-phenylalanine and Ltyrosine with PeF-acetylhypofluorite. obtained in 30 % radiochemical yield based on l$F-acetylhypofluorite within 60 min after the end of irradiation. In rat brain, 30 % of the radioactivity was fixed into acid-insoluble macromolecules and most of the free radioactivity existed as amino acids at one hour after 2-1eF-phenylalanine injection. In the case of 3-leF-tyrosine, significant amounts of radioactivity existed as organic acids. The catecholamine fraction had negligible radioactivity in both cases. These results indicate that 2-leF-phenylalanine is suitable for compartmental analysis for tissue accumulation because of its simple metabolic behavior.

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