1α,25-Dihydroxyvitamin D3 increases IGF binding protein-5 expression in cultured osteoblasts
✍ Scribed by C. Schmid; I. Schläpfer; M.A. Gosteli-Peter; C. Hauri; E.R. Froesch; J. Zapf
- Book ID
- 115932709
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 361 KB
- Volume
- 392
- Category
- Article
- ISSN
- 0014-5793
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The rapid, nongenomic effects of 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3 have been related to a 1,25D3-membrane associated, rapid response steroid binding protein or 1,25D3-[MARRS]bp, with a molecular weight of 65 kDa, in several tissues and species. Currently, no information is available c
## Abstract 1α,25‐Dihydroxyvitamin D~3~ exerts rapid nongenomic effects on rat osteoblast‐like cells independent of the classic nuclear receptor. These effects include changes in phospholipid metabolism and cell calcium. Intracellular calcium itself has been proposed to regulate intracellular pH in