1α,25-Dihydroxyvitamin D3 Increases TGF β1 Binding to Human Osteoblasts
✍ Scribed by David Nagel; Rajiv Kumar
- Book ID
- 115589440
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 98 KB
- Volume
- 290
- Category
- Article
- ISSN
- 0006-291X
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In this communication we describe the synthesis of \(1 \alpha, 25\)-dihydroxyvitamin \(\mathrm{D}_{3}\) - \(3 \beta\)-bromoacetate \(\left[1,25(\mathrm{OH})_{2}-\mathrm{BE}\right]\), an analog of \(1 \alpha, 25\)-dihydroxyvitamin \(\mathrm{D}_{3}\left[1,25(\mathrm{OH})_{2} \mathrm{D}_{3}\right]\), a
The steroid hormone Ia,25-dihydroxyvitamin D3 has been shown to exert rapid effects (1 5 s to 5 min) in osteoblasts. These effects occur in osteoblast-like cells lacking the nuclear vitamin D receptor, ROS 24/1, suggesting that a separate signalling system mediates the rapid actions. These non-genom