𝔖 Bobbio Scriptorium
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[18F]-labeled β1-selective ligands for imaging the adrendergic receptors of the heart

✍ Scribed by J. J. Posakony; T. J. Tewson

Book ID
112132592
Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
79 KB
Volume
44
Category
Article
ISSN
0022-2135

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## Abstract In this study, we synthesized and evaluated a new spirocyclic piperidine derivative 3, containing a 4‐fluorobutyl side chain, as a PET radioligand for neuroimaging of σ~1~ receptors. In vitro, compound 3 displayed high affinity for σ~1~ receptors (__K__~i~=1.2 nM) as well as high select