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A Series of 18F-Labelled Pyridinylphenyl Amides as Subtype-Selective Radioligands for the Dopamine D3 Receptor

✍ Scribed by Carsten Hocke; Simone Maschauer; Harald Hübner; Stefan Löber; Wolfgang Utz; Torsten Kuwert; Peter Gmeiner; Olaf Prante


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
443 KB
Volume
5
Category
Article
ISSN
1860-7179

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✍ Dr. Aurélie Maisonial; Dr. Eva Große Maestrup; Dr. Steffen Fischer; Dr. Achim Hi 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 491 KB 👁 1 views

## Abstract In this study, we synthesized and evaluated a new spirocyclic piperidine derivative 3, containing a 4‐fluorobutyl side chain, as a PET radioligand for neuroimaging of σ~1~ receptors. In vitro, compound 3 displayed high affinity for σ~1~ receptors (__K__~i~=1.2 nM) as well as high select