## Abstract Peptide nucleic acids (PNAs) are a unique class of synthetic macromolecules, originally designed as ligands for the recognition of double stranded DNA. From a chemical point of view, the deoxyribose phosphate backbone of DNA is replaced by a pseudo‐peptide __N__‐(2‐aminoethyl)glycyl bac
[18F] fluorine labeled aliphatic amino acids
✍ Scribed by M. van der Ley
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 365 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The synthesis of 4‐[^18^F] fluoroproline is described, but attempts to prepare 3‐[^18^F] fluoroalanine failed. In the synthetic pathway to this compound different routes are investigated to make a labeled precursor, viz [^18^F] fluoromethyliodide, which, however, were unsuccessful.
📜 SIMILAR VOLUMES
No-Carrier-Added Asymmetric Synthesis of α-Methyl-α-amino Acids Labeled with Fluorine-18. -A short synthesis of the title compounds (VI) which are new radiopharmaceuticals for positron emission tomography is presented ( yields not given or not given exactly). -(DAMHAUT, P.;
## Abstract Exchange of [^18^F]fluoride with ^19^F in various organofluorine compounds in concentrations ranging from 0.06 to 56 mM was explored. We aimed to explore whether exchange reactions can be a potential useful labelling strategy, when there are no requirement of high specific radioactivity
## Abstract The efficient and rapid nucleophilic exchange of fluorine by fluoride‐^18^F ion in aromatic rings is reported here utilizing rubidium‐^18^F‐fluoride in DMSO on model compounds. Specific activities in the 3 × 10^4^ Ci/mol region are readily achievable. Nucleophilic substitution is shown
## Abstract The ^18^F‐labelling of __o__‐fluorohippuric acid by isotope exchange reactions has been studied in several organic solvents under varying reaction conditions. The solvent mixture ethanol/water (1:1) was found suitable for the isotope exchange reaction: a 100 per cent isotope exchange wa
## Abstract Fluorine‐18 labeled 1,1‐difluoro‐2,2‐dichloroethyl aryl ethers have been prepared by a facile ^18^F‐for‐^19^F isotopic exchange reaction. The isotopic exchange proceeds in good to excellent yields (up to 85%), and is dependent on reaction time, temperature, and concentration of reactant