A phase I trial of topically applied tra
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Sheldon A. Weiner; Earl A. Surwit; Vivian E. Graham; Frank L. Meyskens
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Article
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1986
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Springer US
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English
β 260 KB
Forty-two patients were entered into a phase I trial to evaluate the vitamin A derivative, trans-retinoic acid, in cervical intraepithelial neoplasia. Treatment consisted of four consecutive 24-h applications of retinoids via an inert collagen sponge in a cervical cap. Patients were followed for res