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174. Phase I trial of trans-retinoic acid (tra) in solid tumor patients

✍ Scribed by Conley, B; Wu, S; Egorin, M; Hodges, S; Van Echo, D


Book ID
123342408
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
114 KB
Volume
46
Category
Article
ISSN
0753-3322

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A phase I trial of topically applied tra
✍ Sheldon A. Weiner; Earl A. Surwit; Vivian E. Graham; Frank L. Meyskens πŸ“‚ Article πŸ“… 1986 πŸ› Springer US 🌐 English βš– 260 KB

Forty-two patients were entered into a phase I trial to evaluate the vitamin A derivative, trans-retinoic acid, in cervical intraepithelial neoplasia. Treatment consisted of four consecutive 24-h applications of retinoids via an inert collagen sponge in a cervical cap. Patients were followed for res