Phase I clinical trial of all-trans-retinoic acid with correlation of its pharmacokinetics and pharmacodynamics
β Scribed by B. A. Conley; Merrill J. Egorin; Rajeshwari Sridhara; Rebecca Finley; Ramzi Hemady; Suhlan Wu; Nancy S. Tait; David A. Van Echo; David A. Van Echo
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 200 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0344-5704
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Forty-two patients were entered into a phase I trial to evaluate the vitamin A derivative, trans-retinoic acid, in cervical intraepithelial neoplasia. Treatment consisted of four consecutive 24-h applications of retinoids via an inert collagen sponge in a cervical cap. Patients were followed for res
## Abstract ## BACKGROUND Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, induced in vitro differentiation of primary acute myeloid leukemia (AML) blasts, an effect enhanced by allβtrans retinoic acid (ATRA). Clinical responses to VPA were recently observed in patients with myelodyspl
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