## Abstract ^13^C NMR spinβlattice relaxation times (__T__~1~s) and nuclear Overhauser enhancements (NOE's) were measured for a series of clinically used tricyclic antidepressants (TCAs), imipramine (1), amitriptyline (2), doxepin (3) and dothiepin (4), at two magnetic field strengths (correspondin
13C NMR studies of the molecular dynamics of chlorpromazine in solution
β Scribed by Yohko Sakamoto; Tomoko Ishii; Noriko Kurokawa; Toshikazu Aoki; Shigeru Ohshima
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 386 KB
- Volume
- 375
- Category
- Article
- ISSN
- 0022-2860
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## Abstract The ^1^H NMR spectrum of chlorpromazine hydrochloride was fully assigned at 400 MHz. Similarly, the ^13^C NMR spectrum was assigned unambiguously using twoβdimensional NMR. Measurements of chemical shift as a function of concentration in D~2~O showed appreciable changes of shift of both
## Abstract A dynamic study of spirocyclohexanes was carried out using lowβtemperature ^13^C nuclear magnetic resonance spectroscopy. The variations of the energy barrier to inversion of the cyclohexane ring are interpreted in terms of the electronegativity of the heteroatoms of the spiro substitue