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1H and 13C NMR studies of the self-association of chlorpromazine hydrochloride in aqueous solution

✍ Scribed by David Attwood; Roger Waigh; Ross Blundell; Debra Bloor; André Thévand; Elizabeth Boitard; Jean-Paul Dubès; Henri Tachoire

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
393 KB
Volume
32
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The ^1^H NMR spectrum of chlorpromazine hydrochloride was fully assigned at 400 MHz. Similarly, the ^13^C NMR spectrum was assigned unambiguously using two‐dimensional NMR. Measurements of chemical shift as a function of concentration in D~2~O showed appreciable changes of shift of both protons and carbons which were apparent even at solution concentrations two orders of magnitude lower than the critical micelle concentration (CMC). The relative magnitude of the shifts of the aromatic protons and carbons on dilution below the CMC were compatible with vertical stacking of the molecules in an off‐set manner such that maximum overlap of the chlorinated rings occurred. Proton chemical shift data were interpreted using a stepwise association model to quantify the extent of association in the pre‐CMC region.

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