1,3-asymmetric induction in the reduction ofα-alkyl β-Ketosulfoxides with DIBAL/ZnBr2
✍ Scribed by Barros M. David; Carmen Carreño; José L. Garcií Ruano; M.Carmen Maestro
- Book ID
- 108380370
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 330 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
An efficient 1,3-asymetric induction was realized in the reduction of B-keto sutfoxides having various a-substituents with NaBH, under basic conditions and, by the appzication of this induction, CR)-+acetoxyphenyZacetaZdehyde was synthesized.
A novel reaction system is described for the complete stereoselective addition of carbanionic nucleophiles to ,+hydroxy ketones. Controlling l,n-asymmetric induction in nucleophilic addition to acyclic carbonyl compounds is one of the most powerful and useful synthetic methods in organic chemistry.