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Complete 1,3-asymmetric induction in the reactions of allenylboronic acid with β-hydroxy ketones

✍ Scribed by Nobuo Ikeda; Kenichi Omori; Hisashi Yamamoto

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 200 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)84209-4

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✦ Synopsis

A novel reaction system is described for the complete stereoselective addition of carbanionic nucleophiles to ,+hydroxy ketones. Controlling l,n-asymmetric induction in nucleophilic addition to acyclic carbonyl compounds is one of the most powerful and useful synthetic methods in organic chemistry. Recently there has been extensive investigation in this area, and rather reliable methods now exist for achieving good stereoselectivity in additions to ff-and /3-alkoxy aldehydes. 1 Unfortunately,

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