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1,2 asymmetric induction in the TiCl4 mediated alkylation of α-methyl-β-silyloxy ketones with Grignard reagents

✍ Scribed by Giuseppe Bartoli; Marcella Bosco; Letizia Sambri; Enrico Marcantoni


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
206 KB
Volume
38
Category
Article
ISSN
0040-4039

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1,4-syn-Asymmetric induction in the tita
✍ Adriana Lorente; Miquel Pellicena; Pedro Romea; Fèlix Urpí 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 300 KB

Good levels of 1,4-syn asymmetric induction are obtained in the TiCl 4 -mediated aldol reaction of methyl a-silyloxy ketones with achiral aldehydes. Such methodology represents a new approach to the substrate-controlled acetate aldol reaction, which can be useful to design more efficient syntheses o