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1,25-Dihydroxyvitamin D3 up-regulates the renal vitamin D receptor through indirect gene activation and receptor stabilization

✍ Scribed by Kevin D. Healy; Marc A. Frahm; Hector F. DeLuca


Book ID
116177182
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
360 KB
Volume
433
Category
Article
ISSN
0003-9861

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## Abstract Treatment with 10^βˆ’8^ m 1,25‐dihydroxyvitamin D~3~ for 24 h causes transcriptional activation of the human insulin receptor gene in U‐937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinosito