1,25-Dihydroxyvitamin D3 up-regulates the renal vitamin D receptor through indirect gene activation and receptor stabilization
β Scribed by Kevin D. Healy; Marc A. Frahm; Hector F. DeLuca
- Book ID
- 116177182
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 360 KB
- Volume
- 433
- Category
- Article
- ISSN
- 0003-9861
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1β£,25-dihydroxyvitamin D 3 (1β£,25(OH) 2 D 3 ), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D receptor can directly regulate gene expression by binding to
## Abstract Treatment with 10^β8^ m 1,25βdihydroxyvitamin D~3~ for 24 h causes transcriptional activation of the human insulin receptor gene in Uβ937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinosito