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Activation of the human osteocalcin gene by 24r,25-dihydroxyvitamin d3 occurs through the vitamin d receptor and the vitamin d-responsive element

✍ Scribed by Motoyuki Uchida; Keiichi Ozono; Wesley J. Pike

Book ID: 112119373
Publisher: American Society for Bone and Mineral Research
Year: 2009
Tongue: English
Weight: 644 KB
Volume: 9
Category: Article
ISSN: 0884-0431
DOI: 10.1002/jbmr.5650091219

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1␣,25-dihydroxyvitamin D 3 (1␣,25(OH) 2 D 3 ), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D receptor can directly regulate gene expression by binding to