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[11C]WAY 100635: A radioligand for imaging 5-HT1A receptors with positron emission tomography

✍ Scribed by C.A. Mathis; N.R. Simpson; K. Mahmood; P.E. Kinahan; M.A. Mintun

Book ID: 118346525
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 350 KB
Volume: 55
Category: Article
ISSN: 0024-3205
DOI: 10.1016/0024-3205(94)00324-6

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Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding met