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5-HT1A receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-11C]WAY-100635

✍ Scribed by Peter A. Sargent; Eugenii A. Rabiner; Zubin Bhagwagar; Luke Clark; Philip Cowen; Guy M. Goodwin; Paul M. Grasby

Book ID: 113666874
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 352 KB
Volume: 123
Category: Article
ISSN: 0165-0327
DOI: 10.1016/j.jad.2009.07.015

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Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding met