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Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635

✍ Scribed by Anthony J. Cleare; Cristina Messa; Eugenii A. Rabiner; Paul M. Grasby


Book ID
119196586
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
225 KB
Volume
57
Category
Article
ISSN
0006-3223

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Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding met