1.104 ANTIBODIES AGAINST GM1, GD1B AND GQ1B IN PATIENTS WITH PARKINSON'S DISEASE
โ Scribed by E. Hatzifilippou; M. Arnaoutoglou; E. Koutsouraki; V. Costa; S. Baloyannis
- Book ID
- 117754589
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 54 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1353-8020
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Human dorsal root ganglia (DRG), and ventral and dorsal roots were immunostained with rabbit antibodies recognizing GM1, GD1b, or both. Sera from rabbits immunized with GM1 or GD1b were separated in affinity columns into three fractions: Rab1, Rab2, and Rab3. Rab1 recognized only GM1, and Rab2 only
Fifty-nine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GDlb at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incid