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109 DKK4 ACTIVATES NON-CANONICAL JNK SIGNALING PATHWAY WHILE INHIBITING THE WNT-CANONICAL PATHWAY IN HUMAN RENAL CELL CARCINOMA

✍ Scribed by Hirata, Hiroshi; Ueno, Koji; Nakajima, Koichi; Tabatabai, Laura; Hinoda, Yuji; Ishii, Nobuhisa; Carroll, Peter; Dahiya, Rajvir


Book ID
123086883
Publisher
Lippincott Williams and Wilkins
Year
2011
Tongue
English
Weight
37 KB
Volume
185
Category
Article
ISSN
0022-5347

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IGFBP-4 activates the Wnt/beta-catenin s
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## Abstract The Wnt/β‐catenin signaling pathway is inactivated by Wnt antagonists in most cancers and IGFBP‐4 is an antagonist of the Wnt/ β‐catenin signaling pathway. However, the function of IGFBP‐4 is not currently understood in renal cell carcinoma (RCC). We initially found that the expression