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DICKKOPF-4 activates the noncanonical c-Jun-NH2 kinase signaling pathway while inhibiting the Wnt-canonical pathway in human renal cell carcinoma

✍ Scribed by Hiroshi Hirata; Yuji Hinoda; Shahana Majid; Yi Chen; Mohd S. Zaman; Koji Ueno; Koichi Nakajima; Z. Laura Tabatabai; Nobuhisa Ishii; Rajvir Dahiya

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 549 KB
Volume: 117
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.25666

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## Abstract The Wnt/β‐catenin signaling pathway is inactivated by Wnt antagonists in most cancers and IGFBP‐4 is an antagonist of the Wnt/ β‐catenin signaling pathway. However, the function of IGFBP‐4 is not currently understood in renal cell carcinoma (RCC). We initially found that the expression