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108 IGFBP-4 ACTIVATES THE WNT/BETA-CATENIN SIGNALING PATHWAY AND INDUCES M-CAM EXPRESSION IN HUMAN RENAL CELL CARCINOMA

✍ Scribed by Ueno, Koji; Hirata, Hiroshi; Tabatabai, Z. Laura; Hinoda, Yuji; Carroll, Peter R.; Dahiya, Rajvir


Book ID
123097150
Publisher
Lippincott Williams and Wilkins
Year
2011
Tongue
English
Weight
37 KB
Volume
185
Category
Article
ISSN
0022-5347

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IGFBP-4 activates the Wnt/beta-catenin s
✍ Koji Ueno; Hiroshi Hirata; Shahana Majid; Z. Laura Tabatabai; Yuji Hinoda; Rajvi 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 772 KB

## Abstract The Wnt/β‐catenin signaling pathway is inactivated by Wnt antagonists in most cancers and IGFBP‐4 is an antagonist of the Wnt/ β‐catenin signaling pathway. However, the function of IGFBP‐4 is not currently understood in renal cell carcinoma (RCC). We initially found that the expression