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1-(1-Aziridinyl)-3-(2-nitro-1-imidazolyl)-2-propanol [RSU-1069] (I) and 1-(2-methyl-1-aziridinyl)-3-(2-nitro-1-imidazolyl)-2-propanol [RSU-1131] (II)

✍ Scribed by Walton, A. R. ;Jenkins, T. C.


Book ID
114506784
Publisher
International Union of Crystallography
Year
1990
Tongue
English
Weight
454 KB
Volume
46
Category
Article
ISSN
0108-2701

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Synthesis of 1-([18O2]-2-nitro-1-imidazo
✍ Chi-Ching Yang; Irving H. Goldberg πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 499 KB

A short, efficient synthesis for 1-(2-[180 2 ] -n i t r o -1 -i m i d a z o l y l ) -3methoxy-2-propanol ( [ I 8 0 2] -misonidazole) from 2-aminoimidazole is described. The required 180-labeled sodium nitrite (82.6 atom %) was conveiently synthesized by the treatment of sodium nitrite with DOWEX SOW