Synthesis of 1-([18O2]-2-nitro-1-imidazo
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Chi-Ching Yang; Irving H. Goldberg
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Article
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1989
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John Wiley and Sons
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French
โ 499 KB
A short, efficient synthesis for 1-(2-[180 2 ] -n i t r o -1 -i m i d a z o l y l ) -3methoxy-2-propanol ( [ I 8 0 2] -misonidazole) from 2-aminoimidazole is described. The required 180-labeled sodium nitrite (82.6 atom %) was conveiently synthesized by the treatment of sodium nitrite with DOWEX SOW