Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols, [5-tert-Butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanol, and [2-Hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl] ketones
✍ Scribed by Y. Arredondo; M. Moreno-Mañas; R. Pleixats; C. Palacín; M.M. Raga; J.M. Castelló; J.A. Ortiz
- Book ID
- 108480600
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 931 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0968-0896
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## Abstract The increasing clinical importance of drug‐resistant pathogens has lent additional urgency to antimicrobial research. Various 5‐(1‐methyl‐5‐nitro‐2‐imidazolyl)‐4__H__‐1, 2, 4‐triazoles (**4a—6f**) were synthesized and tested __in vitro__ for their antibacterial and antifungal activities
In the title compound, C 6 H 9 N 3 O 2 Se, which is a selenol substituent derivative of metronidazole, all bond lengths and angles are normal. The imidazole ring and nitro group make a dihedral angle of 6.6 (1) , while the N-C-C-Se torsion angle is 59.5 (8) .
l-Methyl-2-nitro-1K-imidazolea carrying d i f f e r e n t 5-side chain. (iaopropyl, hydroxymethylethyl, ethenyl) have been syn- t h e b e d l a b e l l e d with I 4 C a t C2 of t h e imidazole nucleua.
## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l