γ-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-γ-carboxy prothrombin
✍ Scribed by Toru Naraki; Noriatsu Kohno; Hiroyuki Saito; Yoshinori Fujimoto; Motoyuki Ohhira; Takashi Morita; Yutaka Kohgo
- Book ID
- 117617872
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 282 KB
- Volume
- 1586
- Category
- Article
- ISSN
- 0925-4439
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Des-y-carboxy prothrombin [DCP], a protein induced by vitamin K absence or antagonist-I1 and also abbreviated PIVKA-11, was evaluated as a serologic marker for hepatocellular carcinoma (HCC). Its plasma levels were measured by enzyme immunoassay (E-1023) using an anti-DCP monoclonal antibody in 514
Des-y-carboxy (abnormal) prothrombin (DCP) is a newly described tumor marker for HCC (I). In 1984, Liebman et al. found DCP in the plasma of nearly 90% of patients with HCC, suggesting that this protein could be utilized as a tumor marker for this malignancy. Since the initial report, this observati