Des-γ-carboxy prothrombin is an autocrine mitogen for hepatocellular carcinoma
✍ Scribed by Suzuki, Mayumi; Shiraha, Hidenori; Fujikawa, Tatsuya; Takaoka, Nobuyuki; Takaki, Akinobu; Nakanishi, Yutaka; Ueda, Naoki; Koike, Kazuko; Sakaguchi, Kohsaku; Shiraton, Yasushi
- Book ID
- 123355293
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 179 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## BACKGROUND Des‐γ‐carboxy prothrombin (DCP) has been reported to be an important prognostic factor in patients with hepatocellular carcinoma (HCC). Recently, a monoclonal antibody, 19B7, which recognizes the Gla domain of DCP, has been identified. The 19B7 antibody recognizes an epit
Des-y-carboxy prothrombin [DCP], a protein induced by vitamin K absence or antagonist-I1 and also abbreviated PIVKA-11, was evaluated as a serologic marker for hepatocellular carcinoma (HCC). Its plasma levels were measured by enzyme immunoassay (E-1023) using an anti-DCP monoclonal antibody in 514
Des-y-carboxy (abnormal) prothrombin (DCP) is a newly described tumor marker for HCC (I). In 1984, Liebman et al. found DCP in the plasma of nearly 90% of patients with HCC, suggesting that this protein could be utilized as a tumor marker for this malignancy. Since the initial report, this observati