𝔖 Bobbio Scriptorium
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β-Secretase: its biology as a therapeutic target in diseases

✍ Scribed by Wang, Haibo; Li, Rena; Shen, Yong


Book ID
120089378
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
854 KB
Volume
34
Category
Article
ISSN
0165-6147

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## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we