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β-Secretase (BACE) as a drug target for alzheimer’s disease

✍ Scribed by Robert Vassar

Book ID
114176128
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
521 KB
Volume
54
Category
Article
ISSN
0169-409X

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## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we