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β-Secretase Inhibitors for the Treatment of Alzheimer’s Disease and Down’s Syndrome

✍ Scribed by Abdel-Magid, Ahmed F.

Book ID
127174172
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
246 KB
Volume
4
Category
Article
ISSN
1948-5875

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## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we