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β-Secretase inhibition for the treatment of Alzheimer's disease – promise and challenge

✍ Scribed by Martin Citron

Book ID
116918374
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
373 KB
Volume
25
Category
Article
ISSN
0165-6147

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✍ Martin Citron 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 490 KB 👁 1 views

## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we