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Potential treatment opportunities for Alzheimer’s disease through inhibition of secretases and Aβ immunization

✍ Scribed by Dale Schenk; Dora Games; Peter Seubert

Book ID
111639569
Publisher
Humana Press Inc
Year
2001
Tongue
English
Weight
156 KB
Volume
17
Category
Article
ISSN
0895-8696

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✍ Martin Citron 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 490 KB 👁 1 views

## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we