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β-Lactam synthesis: Cyclization versus 1,2-acyl migration-cyclization. The mechanism of the 1,2-acyl migration-cyclization

✍ Scribed by Jollie D Godfrey Jr.; Richard H Mueller; Derek J Von Langen

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 218 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)84644-4

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✦ Synopsis

The cyclization of hydroxamate 1 unexpectedly afforded two isomeric @lactams 2 and 1. The mechanism for the formation of 2 has been shown by carbon-13 labeling to involve a novel 1,2-acyl migration-cyclization process.

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