𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A convenient synthesis of the β-lactam ring by 3 + 1 cyclization

✍ Scribed by Koichi Hirai; Yuji Iwano


Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
174 KB
Volume
20
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


The synthesis of β-lactams by the cycliz
✍ Harry H. Wasserman; Dennis J. Hlasta; Alan W. Tremper; James S. Wu 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 192 KB

There has been considerable recent interest in the synthesis of monocyclic 6-lactams as a result of the isolation, from fermentation cultures, of antibiotics such as nocardicin A (1j1,2.3 and the observation of the remarkably high antimicrobial activity associated with these products.'

β-Lactam synthesis: Cyclization versus 1
✍ Jollie D Godfrey Jr.; Richard H Mueller; Derek J Von Langen 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 218 KB

The cyclization of hydroxamate 1 unexpectedly afforded two isomeric @lactams 2 and 1. The mechanism for the formation of 2 has been shown by carbon-13 labeling to involve a novel 1,2-acyl migration-cyclization process.

A convenient synthesis of azetidine-2,3-
✍ M.S Manhas; S.S Bari; B.M Bhawal; Ajay K Bose 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 188 KB

Summaryz Azetidine-2,3-dionee can be conveniently synthesized by mild hydrolysis of the product of the reaction between a-phenylthio-&la&ems and sulfuryl chloride.

Synthetic studies on β-lactam antibiotic
✍ Tsutomu Aoki; Mitsuru Yoshioka; Yuji Sendo; Wataru Nagata 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 248 KB

Alcohols 4\_ and s prepared from 3 underwent completely stereospecific etherification to give l-oxacephams 2 and s which were converted into the 1-oxacephem nucleus 2 via kaand lc. Functionalization at C-3' in 6 and &was unsuccessful. Since 7a-methoxy-1-oxacephem & (6059-S) was found to be a highly