𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tandem Double-Michael-Addition/Cyclization/Acyl Migration of 1,4-Dien-3-ones and Ethyl Isocyanoacetate: Stereoselective Synthesis of Pyrrolizidines

✍ Scribed by Jing Tan; Xianxiu Xu; Lingjuan Zhang; Yifei Li; Qun Liu


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
611 KB
Volume
121
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Tandem Double-Michael-Addition/Cyclizati
✍ Jing Tan; Xianxiu Xu; Lingjuan Zhang; Yifei Li; Qun Liu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 611 KB

## Abstract **Up to four adjacent stereocenters** can be formed stereoselectively in the construction of a pyrrolizidine unit through a novel organocatalytic reaction that involves treatment of various dienones with ethyl isocyanoacetate (see scheme; DBU=1,8‐diazabicyclo[5.4.0]undec‐7‐ene). Mechani