β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region
✍ Scribed by M.A Bender; Michael Bulger; Jennie Close; Mark Groudine
- Book ID
- 117736398
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 184 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1097-2765
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Using ligation-mediated PCR and in vivo footprinting methods to study the status of DNA-protein interaction at hypersensitive site 2 of locus control region and  maj promoter of erythroid cells of fetal liver and adult bone marrow, we found that during different developmental periods, the status of
Sequence polymorphisms within the 5'HS2 segment of human locus control region is described among sickle cell anemia patients. Distinct polymorphic patterns of a simple sequence repeat are observed in strong linkage disequilibrium with each of the five major beta s haplotypes. Potential functional re