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Inter-ethnic polymorphism of the β-globin gene locus control region (LCR) in sickle-cell anemia patients

✍ Scribed by Bruno Périchon; Angela Ragusa; Claudine Lapouméroulie; Alain Romand; Paolo Moi; Tohru Ikuta; Dominique Labie; Jacques Elion; Rajagopal Krishnamoorthy

Publisher
Springer
Year
1993
Tongue
English
Weight
612 KB
Volume
91
Category
Article
ISSN
0340-6717

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✦ Synopsis

Sequence polymorphisms within the 5'HS2 segment of human locus control region is described among sickle cell anemia patients. Distinct polymorphic patterns of a simple sequence repeat are observed in strong linkage disequilibrium with each of the five major beta s haplotypes. Potential functional relevance of this polymorphic region in globin gene expression is discussed.

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