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α-Lipoic acid exhibits anti-amyloidogenicity for β-amyloid fibrils in vitro

✍ Scribed by Kenjiro Ono; Mie Hirohata; Masahito Yamada

Book ID
116292258
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
277 KB
Volume
341
Category
Article
ISSN
0006-291X

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## Abstract Inhibition of the accumulation of amyloid β‐peptide (Aβ) and the formation of β‐amyloid fibrils (fAβ) from Aβ, as well as the destabilization of preformed fAβ in the central nervous system, would be attractive therapeutic targets for the treatment of Alzheimer's disease (AD). We reporte