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α-Iodocycloalkenones: Synthesis of (±)-epibatidine

✍ Scribed by Nilantha S. Sirisoma; Carl R. Johnson

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 191 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00187-7

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✦ Synopsis

A synthesis of the non-opiate analgesic alkaloid epibatidine was achieved in 13 steps and 13% overall yield starting from 1,3-cyclohexadiene using in a key step a modified Stille coupling reaction on an c~-iodocyclohexenone.

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