A synthesis of the non-opiate analgesic alkaloid epibatidine was achieved in 13 steps and 13% overall yield starting from 1,3-cyclohexadiene using in a key step a modified Stille coupling reaction on an c~-iodocyclohexenone.
✦ LIBER ✦
Synthesis of β-substituted α-iodocycloalkenones
✍ Scribed by Chin-Kang Sha; Shih-Jung Huang
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 90 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
α-Iodocycloalkenones: Synthesis of (±)-e
✍
Nilantha S. Sirisoma; Carl R. Johnson
📂
Article
📅
1998
🏛
Elsevier Science
🌐
French
⚖ 191 KB
ChemInform Abstract: α-Iodocycloalkenone
✍
N. S. SIRISOMA; C. R. JOHNSON
📂
Article
📅
2010
🏛
John Wiley and Sons
⚖ 36 KB
👁 1 views
Synthesis of α-Substituted-α-Amido-β-Lac
✍
Ajay K. Bose; J.C. Kapur; B. Dayal; M.S. Manhas
📂
Article
📅
1973
🏛
Elsevier Science
🌐
French
⚖ 176 KB
Synthesis of α-substituted α,β-unsaturat
✍
Marcus A Tius; Huaping Hu
📂
Article
📅
1998
🏛
Elsevier Science
🌐
French
⚖ 190 KB
~-Deprotonation of tert-butyldimethylsilyloxy allene is followed by silyl migration froln oxygen to cm'bon. The resulting C-nucleophile adds to aldehydes to generate cql£uusaturated acylsilanes.
Asymmetric Synthesis of α- and α,β-Subst
✍
Dieter Enders; Jean-Claude Adelbrecht; Wacharee Harnying
📂
Article
📅
2006
🏛
John Wiley and Sons
⚖ 38 KB
👁 1 views
Diastereoselective synthesis of α-substi
✍
Géraldine Castelot-Deliencourt; Xavier Pannecoucke; Jean-Charles Quirion
📂
Article
📅
2001
🏛
Elsevier Science
🌐
French
⚖ 75 KB
A simple and general asymmetric synthesis of b-amidophosphonates is described. The method involves the highly selective addition (up to 95% d.e.) of diethyl phosphite to various chiral a,b-unsaturated carboxylic amides derived from chiral aminoalcohols.