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α-Globin gene organisation in blacks precludes the severe form of α-thalassaemia

✍ Scribed by DOZY, A. M.; KAN, Y. W.; EMBURY, S. H.; MENTZER, W. C.; WANG, W. C.; LUBIN, B.; DAVIS, J. R.; KOENIG, H. M.


Book ID
109715830
Publisher
Nature Publishing Group
Year
1979
Tongue
English
Weight
338 KB
Volume
280
Category
Article
ISSN
0028-0836

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A new unstable -globin chain associated with -thalassemia phenotype has been found in a Spanish patient. Molecular analysis of the -globin gene complex using PCR and non-radioactive single-strand conformation analysis, allowed to identify a new mutation in the second exon of the 1 -globin gene. Dire