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Partial deletion of the α-globin structural gene in human α-thalassaemia

✍ Scribed by Orkin, Stuart H.; Michelson, Alan


Book ID
109719288
Publisher
Nature Publishing Group
Year
1980
Tongue
English
Weight
429 KB
Volume
286
Category
Article
ISSN
0028-0836

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A new unstable -globin chain associated with -thalassemia phenotype has been found in a Spanish patient. Molecular analysis of the -globin gene complex using PCR and non-radioactive single-strand conformation analysis, allowed to identify a new mutation in the second exon of the 1 -globin gene. Dire