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Gene deletion as the cause of α thalassaemia: The severe form of α thalassaemia is caused by a haemoglobin gene deletion

✍ Scribed by OTTOLENGHI, SERGIO; LANYON, W. GEORGE; PAUL, JOHN; WILLIAMSON, ROBERT; WEATHERALL, D. J.; CLEGG, J. B.; PRITCHARD, JON; POOTRAKUL, S.; BOON, WONG HOCK


Book ID
109692934
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
488 KB
Volume
251
Category
Article
ISSN
0028-0836

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α-thalassaemia due to a single codon del
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A new unstable -globin chain associated with -thalassemia phenotype has been found in a Spanish patient. Molecular analysis of the -globin gene complex using PCR and non-radioactive single-strand conformation analysis, allowed to identify a new mutation in the second exon of the 1 -globin gene. Dire