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α-Fluorination of 6-phenylsulfinyl-2-azabicyclo[2.2.1]heptan-3-one and synthesis of 2′-fluoro substituted carbovir

✍ Scribed by Akemi Toyota; Akiko Nishimura; Chikara Kaneko

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
185 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Fluorination of phenylsulfinyl bicycloamide using molecular fluorine proceeded preferentially with inversion of the carbon atom having the sulfinyl group to afford a-fluorinated sulfonyl bicycloamide in fair yield. The fluorinated sulfonyl bicycloamide was converted to 2'fluoro substituted carbovir v/a reductive desulfonylchlorination.

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