✦ LIBER ✦

α-1-Antichymotrypsin variant detected by PCR-single strand conformation polymorphism (PCR-SSCP) and direct sequencing

✍ Scribed by Michio Tsuda; Yukari Sei; Masahiko Matsumoto; Hiroshi Kamiguchi; Masahiro Yamamoto; Yukito Shinohara; Tsuyoshi Igarashi; Masaichi Yamamura

Book ID: 104669520
Publisher: Springer
Year: 1992
Tongue: English
Weight: 232 KB
Volume: 90
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00220480

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✦ Synopsis

A new mutant alpha-1-antichymotrypsin (variant ACT) was found by polymerase chain reaction single strand conformation polymorphism and direct sequencing. In this variant ACT, two bases (AA) were deleted from codon 391. This resulted in a different amino acid sequence downstream of the deletion point, elongating the peptide chain by 10 amino acids.

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