𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Über Pterinchemie. 85. Mitteilung. Polyacetylierte 5,6,7,8-Tetrahydro-D- und -L-neopterine. Ein besonderer Fall von N(5)-Alkylierung des 5,6,7,8-Tetrahydroneopterin-Gerüstes

✍ Scribed by Syméon Antoulas; Roland Prewo; Jost H. Bieri; Max Viscontini

Publisher
John Wiley and Sons
Year
1986
Tongue
German
Weight
473 KB
Volume
69
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Polyacetylated 5,6,7,8-Tetrahydro-D-and -bneopterins. A Special Case of N(5)-Alkylation of 5,6,7,8-Tetrahydroneopterins

Improved conditions are reported for the preparation of the earlier described (6R)-and (6S)-l'-0,2'-0,3'-0,2-N,5-pentaacetyl-5,6,7,8-tetrahydro-~-neopterins, one of which could be obtained as pure crystals. Its structure, determined by X-ray-diffraction analysis, corresponds to the (6R)-enantiomer. The method has also been used to make the corresponding D-diastereoisomers. Further acetylation of (6RS)-1 '-0,2'-0,3'-0,2-N-tetraacety1-5,6,7,8tetrahydro-D-neopterin under drastic conditions yields a mixture of several polyacetylated u-neopterin derivatives and a polyacetylated ethyl-tetrahydro-D-neopterin which was isolated in crystalline form and established by X-ray-diffraction analysis to be (6R)-1'-0,2'-0,3'-0,4-0,2-N,2-N,8-heptaacetyl-5-ethyl-5,6,7,8-tetrahydro-~neopterin.

') 84.

📜 SIMILAR VOLUMES

Über Pterinchemie. 55. Mitteilung [1]. R
Über Pterinchemie. 55. Mitteilung [1]. Reindarstellung und Charakterisierung von 5,6,7,8-Tetrahydro-L-neopterin und 5,6,7,8-Tetrahydro-D-monapterin
✍ Bernhard Schircks; Jost H. Bieri; Max Viscontini 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 German ⚖ 280 KB

**Preparation and characterisation of pure 5,6,7,8‐tetrahydro‐L‐neopterine und 5,6,7,8‐tetrahydro‐D‐monapterine**. The synthesis of these two compounds, III and IV, is described, and their structures ascertained by means of ^1^H‐NMR., ^13^C‐NMR. and FD. spectroscopy. In particular the possibility o

Über Pterinchemie 81. Mitteilung Die Kon
Über Pterinchemie 81. Mitteilung Die Konfiguration an C(6) von natürlichem 5,6,7,8-Tetrahydro-L-biopterin und seinem Pentaacetylderivat
✍ Roland Prewo; Jost H. Bieri; Subhendu Narayan Ganguly; Max Viscontini 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 German ⚖ 314 KB 👁 1 views

**The Configuration at C(6) of Natural 5,6,7,8‐Tetrahydro‐L‐biopterin and of its Pentaacetate** The structure of (6.__R__)‐pentaacetyl‐5,6,7,8‐tetrahydro‐L‐biopterin, one of two diastereoisomers obtained by catalytic hydrogenation and subsequent acetylation of L‐biopterin, has been determined by X‐

Über Pterinchemie 80. Mitteilung Die Her
Über Pterinchemie 80. Mitteilung Die Herstellung von (6RS)Tetra- und (6RS)Pentaacetyl-5,6,7,8-tetrahydro-L-bioplerinen
✍ Subhendu Narayaa Ganguly; Max Viscontini 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 German ⚖ 191 KB 👁 1 views

**Preparation of (6__RS__)Tetra‐ and (6__RS__)‐Pentaacetyl‐5,6,7,8‐tetrahydro‐L‐biopterines** Boiling of (6__RS__) l′‐__O__,2′‐__O__,2‐N‐triacetyl‐5,6,7,8‐tetrahydro‐L‐biopterine in acetic anhydride as described in [2], leads to a mixture of the diastereoisomeric (6__R__)‐ and (65)‐l′‐__O__,2′‐__O_

Über Pterinchemie. 65 Mitteilung [1]. He
Über Pterinchemie. 65 Mitteilung [1]. Herstellung von (6 R, S)-5,6,7,8-Tetrahydro-L-biopterin, 7,8-Dihydro-L-biopterin, L-Sepiapterin, Deoxysepiapterin, (6 R, S)-5,6-Dihydrodeoxysepiapterin und 2′-Deoxybiopterin
✍ Bernhard Schircks; Jost H. Bieri; Max Viscontini 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 German ⚖ 437 KB

**Preparation of (6 __R__, __S__)‐5,6,7,8‐tetrahydro‐L‐biopterine, 7,8‐dihydro‐L‐biopterine, L‐sepiapterine, deoxysepiapterine, (6 __R__, __S__)‐5,6‐dihydrodeoxysepiapterine and 2′‐deoxybiopterine** We describe the preparation of (6 __R__, __S__)‐5,6,7,8‐tetrahydro‐L‐biopterine (II) by catalytic‐ (

Über Pterinchemie. 79. Mitteilung. 13C-u
Über Pterinchemie. 79. Mitteilung. 13C-und 15N-NMR.-spektroskopische Untersuchungen an der (6RS)-5, 10-Methylen-5, 6, 7, 8-tetrahydro-L-folsäure; eindeutiger Beweis ihrer Struktur
✍ Roger Kalbermatten; Werner Städeli; Jost H. Bieri; Max Viscontini 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 German ⚖ 429 KB

**^13^C‐ and ^15^N‐NMR.‐Spectroscopic Studies on (__6RS__)‐5, 10‐Methylene‐5, 6, 7, 8‐tetrahydro‐L‐folic Acid; Unequivocal Proof of thier Structure** The existence of a 5, 10‐methylene bridge in the title compound has been established with the help of ^15^N‐NMR, and ^13^C‐NMR. spectroscopy. The sim