**Separation of the Diastereomers (6__R__) and (6__S__)‐5,6,7,8‐Tetrahydro‐L‐neopterin** The mixture of the diastereomers of the pentaacetylderivative IV of (6__RS__)‐5,6,7,8‐tetrahydro‐L‐neopterins could be separated by fractional crystallisation in methanol into the diastereomers IV A and IV B. H
Über Pterinchemie. 55. Mitteilung [1]. Reindarstellung und Charakterisierung von 5,6,7,8-Tetrahydro-L-neopterin und 5,6,7,8-Tetrahydro-D-monapterin
✍ Scribed by Bernhard Schircks; Jost H. Bieri; Max Viscontini
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- German
- Weight
- 280 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Preparation and characterisation of pure 5,6,7,8‐tetrahydro‐L‐neopterine und 5,6,7,8‐tetrahydro‐D‐monapterine.
The synthesis of these two compounds, III and IV, is described, and their structures ascertained by means of ^1^H‐NMR., ^13^C‐NMR. and FD. spectroscopy. In particular the possibility of detecting diastereomeric pairs of types III and IV in ^13^C‐NMR. spectra is discussed.
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## Gedenken (1
Polyacetylated 5,6,7,8-Tetrahydro-D-and -bneopterins. A Special Case of N(5)-Alkylation of 5,6,7,8-Tetrahydroneopterins Improved conditions are reported for the preparation of the earlier described (6R)-and (6S)-l'-0,2'-0,3'-0,2-N,5-pentaacetyl-5,6,7,8-tetrahydro-~-neopterins, one of which could be
**Preparation of (6__RS__)Tetra‐ and (6__RS__)‐Pentaacetyl‐5,6,7,8‐tetrahydro‐L‐biopterines** Boiling of (6__RS__) l′‐__O__,2′‐__O__,2‐N‐triacetyl‐5,6,7,8‐tetrahydro‐L‐biopterine in acetic anhydride as described in [2], leads to a mixture of the diastereoisomeric (6__R__)‐ and (65)‐l′‐__O__,2′‐__O_
**Configuration and conformation of 6,7‐Dimethyl‐ and 5,6,7‐Trimethyl‐5,6,7,8‐tetrahydropterines.** During the hydrogenation of 6,7‐dimethylpterine, __cis__‐6,7‐dimethyl‐tetrahydropterine is formed. A possible conformation for this substance and for the 5,6,7‐trimethyl derivative, which is obtained