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Über Pterinchemie. 65 Mitteilung [1]. Herstellung von (6 R, S)-5,6,7,8-Tetrahydro-L-biopterin, 7,8-Dihydro-L-biopterin, L-Sepiapterin, Deoxysepiapterin, (6 R, S)-5,6-Dihydrodeoxysepiapterin und 2′-Deoxybiopterin

✍ Scribed by Bernhard Schircks; Jost H. Bieri; Max Viscontini

Publisher
John Wiley and Sons
Year
1978
Tongue
German
Weight
437 KB
Volume
61
Category
Article
ISSN
0018-019X

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✦ Synopsis

Preparation of (6 R, S)‐5,6,7,8‐tetrahydro‐L‐biopterine, 7,8‐dihydro‐L‐biopterine, L‐sepiapterine, deoxysepiapterine, (6 R, S)‐5,6‐dihydrodeoxysepiapterine and 2′‐deoxybiopterine

We describe the preparation of (6 R, S)‐5,6,7,8‐tetrahydro‐L‐biopterine (II) by catalytic‐ (reported in our short communication [2]) and natriumdithionite reduction of L‐biopterine (I) and a preparation of 7,8‐dihydro‐L‐biopterine (IV) by treatment of L‐biopterine (I) with natriumdithionite. Whereas oxidation of tetrahydrobiopterine II in the presence of oxygen leads to L‐sepiapterine (III), dihydrobiopterine IV in acetic acid without oxygen gives deoxysepiapterine (VII), 5,6‐dihydro‐deoxysepiapterine (VI) and 2′‐deoxybiopterine (V) by a disproportionation reaction.

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