𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung

✍ Scribed by A. E. Wilder Smith; Emil Hofstetter

Publisher
John Wiley and Sons
Year
1955
Tongue
German
Weight
583 KB
Volume
38
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The preparation and properties of further fatty acid anilides showing anaesthetic action are described and the relationship between chemical constitution and physiological effect is discussed. Two very active compounds having relatively low toxicities have been discovered, namely:‐

β‐piperidino‐n‐butyric‐acid‐2,4‐dichloranilide (XIV) and β‐(2‐methylpiperidino)‐n‐butyric‐acid‐anilide (V). A number of similar anilides show high activities, but other undesirable properties such as tissue irritation render them less useful.

📜 SIMILAR VOLUMES

Über einige β-substituierte Fettsäureami
Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung. 4. Mitteilung
✍ A. E. Wilder Smith 📂 Article 📅 1959 🏛 John Wiley and Sons 🌐 German ⚖ 343 KB 👁 1 views

## Abstract The preparation and properties of some new β‐alkylamino‐butyric anilides have been described and a summary report on some of their pharmacological properties is given. Two derivatives (the p‐(carbo‐n‐butoxy)‐anilides of β‐diethylamino‐ and of β‐(1‐piperidino)‐ butyric acid = XVI and XVI

Über einige β-substituierte Fettsäureami
Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung. 5. Mitteilung
✍ A. E. Wilder Smith 📂 Article 📅 1959 🏛 John Wiley and Sons 🌐 German ⚖ 407 KB 👁 1 views

## Abstract A further series of butyric acid amides has been synthesised in which the diethylamino, pyrrolidino and piperidino groups of previously reported syntheses have been substituted by morpholino groups. The influence of the various groups in the present and in previously reported derivative

Über einige β-Dialkylaminobuttersäureami
Über einige β-Dialkylaminobuttersäureamide mit anästhetischer Wirkung
✍ Emil Hofstetter; A. E. Wilder Smith 📂 Article 📅 1953 🏛 John Wiley and Sons 🌐 German ⚖ 449 KB 👁 1 views

## Abstract The preparation of some β‐alkylaminobutyric‐acid‐amides from the corresponding crotonic acid amides and dimethyl or diethylamine under pressure at 100–150° is described. Two diethylamino acetic acid amides were prepared by reacting N‐benzyl‐chloracetamide or N‐(pethoxybenzyl)‐chloraceta

Über die Darstellung von Alkylaminoäthyl
Über die Darstellung von Alkylaminoäthylestern einiger Aminosalicylsäuren mit lokalanästhetischer Wirkung
✍ Grimme, Walter ;Schmitz, Heimich 📂 Article 📅 1951 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 722 KB

## Abstract Es wird die Herstellung nach verschiedenen Verfahren einiger Dialkylaminoäthylester der 4‐Amino‐salicylsäure, der 5‐Amino‐salicylsäure sowie analoger Ester der __N__‐mono‐alkylierten, bzw. __N__‐mono‐alkyloxy‐alkylierten Aminosalicylsäuren beschrieben, die z.Tl. hervorragende lokalanäst